Legend® (hyaluronate sodium) Injectable Solution is a sterile, pyrogen-free, FDA-approved veterinary pharmaceutical manufactured by Boehringer Ingelheim Animal Health. It is specifically indicated for the treatment of joint dysfunction of the carpus (knee) or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis . This product provides targeted therapy for performance horses, show animals, and pleasure horses suffering from inflammation of the synovial membrane — the tissue lining the joint capsule.
Indications and Usage
Legend Injectable Solution is indicated for the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis .The primary therapeutic goal is to restore the viscoelastic properties of the synovial fluid, reduce inflammation, and improve joint function and mobility.
Key indications include:
- Lameness associated with carpal or fetlock osteoarthritis
- Non-infectious synovitis (inflammation of the synovial membrane)
- Joint effusion (fluid accumulation) secondary to osteoarthritis
- Reduced range of motion in the affected joint
Specifications
| Parameter | Specification |
|---|---|
| Product Name | Legend® Injectable Solution |
| Active Ingredient | Hyaluronate Sodium |
| Concentration | 10 mg/mL |
| Package Size | 6 × 4 mL single-dose vials |
| Total Active per Vial | 40 mg hyaluronate sodium per 4 mL vial |
| Dosage Form | Sterile, pyrogen-free injectable solution |
| Route of Administration | Intra-articular injection (into the carpus or fetlock joint) |
| FDA Status | Approved under NADA # 140-883 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Inactive Ingredients per mL | Sodium Chloride (8.5 mg), Sodium Phosphate Dibasic (0.223 mg), Sodium Phosphate Monobasic (0.04 mg) |
| pH | 6.8 – 7.6 |
| Storage Conditions | Store at controlled room temperature 20–25°C (68–77°F). Brief excursions to 40°C (104°F) are permitted. Do not freeze. |
| Shelf Life | As indicated on the vial label (typically 2–3 years from manufacture) |
| Species | Equine (horses) |
| Target Joints | Carpus (knee) and fetlock |
| Treatment Regimen | May be repeated at weekly intervals for a total of three treatments, as directed by the veterinarian |
Directions for Use
- Pre-treatment evaluation: A thorough lameness examination, including radiographic evaluation, should be performed to confirm the diagnosis and rule out serious fractures or other pathologies.
- Joint preparation: The injection site should be clipped, surgically scrubbed, and prepared using strict aseptic technique.
- Administration: The 4 mL single-dose vial is drawn into a sterile syringe and injected directly into the affected joint space using an appropriate gauge needle.
- Post-injection care: The horse should be rested or given controlled exercise for 24–48 hours post-injection. The treating veterinarian will determine the appropriate post-injection management plan.
- Repeat treatments: Treatment may be repeated at weekly intervals for a total of three treatments, depending on the horse’s response and the veterinarian’s clinical judgment.
Special Precautions and Warnings
- Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures before administering Legend.
- Aseptic technique is critical. As with any intra-articular treatment, special precautions must be followed regarding injection technique and sterility for the prevention of possible swelling or infection.
- Do not inject through compromised skin. Intra-articular injections should not be made through skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it.
- Do not use in horses with known hypersensitivity to hyaluronate sodium or any of the excipients.
- Keep out of reach of children.
- For veterinary use only.
- Not for human use.
Storage and Handling
- Store at controlled room temperature (20–25°C / 68–77°F).
- Brief excursions up to 40°C (104°F) are permitted.
- Do not freeze.
- Protect from light.
- Use only clear, particle-free solutions. Do not use if the solution is discolored or contains visible particulates.
- Discard any unused portion of the single-dose vial.
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